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secreted phosphoprotein 1 (spp1)  (Informa UK Limited)

 
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    Informa UK Limited secreted phosphoprotein 1 (spp1)
    Secreted Phosphoprotein 1 (Spp1), supplied by Informa UK Limited, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/secreted+phosphoprotein+1+%28spp1%29/pm40275639-26-18-13?v=Informa+UK+Limited
    Average 90 stars, based on 1 article reviews
    secreted phosphoprotein 1 (spp1) - by Bioz Stars, 2026-08
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    The RNA expression level of SPP1 in different types of cancer. (A) The SPP1 expression level in tumor and normal tissues in the TIMER2 database (*, P<0.05; **, P<0.01; ***, P<0.001). (B) The expression level of SPP1 in DLBC, LGG, OV, TGCT, and UCS tumor tissues and the corresponding normal tissues of the GTEx database using GEPIA2 (*, P<0.01). (C) Relationship between SPP1 and the pathological stages of BLCA, CESC, ESCA, HNSC, TGCT, LIHC, SKCM, and THCA tumor types. SPP1, secreted phosphoprotein 1; DLBC, diffuse large B cell lymphoma; LGG, brain lower grade glioma; OV, ovarian serous cystadenocarcinoma; TGCT, testicular germ cell tumor; UCS, uterine carcinosarcoma; GTEx, Genotype-Tissue Expression; BLCA, bladder urothelial carcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma; ESCA, esophageal carcinoma; HNSC, head and neck squamous cell cancer; LIHC, liver hepatocellular cancer; SKCM, skin cutaneous melanoma; THCA, thyroid carcinoma.
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    The RNA expression level of SPP1 in different types of cancer. (A) The SPP1 expression level in tumor and normal tissues in the TIMER2 database (*, P<0.05; **, P<0.01; ***, P<0.001). (B) The expression level of SPP1 in DLBC, LGG, OV, TGCT, and UCS tumor tissues and the corresponding normal tissues of the GTEx database using GEPIA2 (*, P<0.01). (C) Relationship between SPP1 and the pathological stages of BLCA, CESC, ESCA, HNSC, TGCT, LIHC, SKCM, and THCA tumor types. SPP1, secreted phosphoprotein 1; DLBC, diffuse large B cell lymphoma; LGG, brain lower grade glioma; OV, ovarian serous cystadenocarcinoma; TGCT, testicular germ cell tumor; UCS, uterine carcinosarcoma; GTEx, Genotype-Tissue Expression; BLCA, bladder urothelial carcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma; ESCA, esophageal carcinoma; HNSC, head and neck squamous cell cancer; LIHC, liver hepatocellular cancer; SKCM, skin cutaneous melanoma; THCA, thyroid carcinoma.
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    Image Search Results


    Therapeutic response prediction and immunohistochemistry of SPP1. (A) Sensitivity to sorafenib by risk group. (B) Response rate to ICB therapy. (C) Heatmap showing the correlation between risk score and the three model genes. (D) Representative immunohistochemically stained images of HCC tissues showing SPP1 expression (upper, 5.0×; lower, 20.0×). (E) K-M OS curves of 19 HCC patients with different SPP1 levels.

    Journal: Frontiers in Oncology

    Article Title: Dissecting a hypoxia-related angiogenic gene signature for predicting prognosis and immune status in hepatocellular carcinoma

    doi: 10.3389/fonc.2022.978050

    Figure Lengend Snippet: Therapeutic response prediction and immunohistochemistry of SPP1. (A) Sensitivity to sorafenib by risk group. (B) Response rate to ICB therapy. (C) Heatmap showing the correlation between risk score and the three model genes. (D) Representative immunohistochemically stained images of HCC tissues showing SPP1 expression (upper, 5.0×; lower, 20.0×). (E) K-M OS curves of 19 HCC patients with different SPP1 levels.

    Article Snippet: After blocking with goat serum at room temperature for 1 h, the tissues were sequentially incubated with an anti-secreted phosphoprotein-1 (SPP1) antibody (1:100, 22952-1-AP; Proteintech, Rosemont, IL, USA) at 4°C overnight and a secondary antibody at room temperature for 1 hour.

    Techniques: Clinical Proteomics, Immunohistochemistry, Staining, Expressing

    The RNA expression level of SPP1 in different types of cancer. (A) The SPP1 expression level in tumor and normal tissues in the TIMER2 database (*, P<0.05; **, P<0.01; ***, P<0.001). (B) The expression level of SPP1 in DLBC, LGG, OV, TGCT, and UCS tumor tissues and the corresponding normal tissues of the GTEx database using GEPIA2 (*, P<0.01). (C) Relationship between SPP1 and the pathological stages of BLCA, CESC, ESCA, HNSC, TGCT, LIHC, SKCM, and THCA tumor types. SPP1, secreted phosphoprotein 1; DLBC, diffuse large B cell lymphoma; LGG, brain lower grade glioma; OV, ovarian serous cystadenocarcinoma; TGCT, testicular germ cell tumor; UCS, uterine carcinosarcoma; GTEx, Genotype-Tissue Expression; BLCA, bladder urothelial carcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma; ESCA, esophageal carcinoma; HNSC, head and neck squamous cell cancer; LIHC, liver hepatocellular cancer; SKCM, skin cutaneous melanoma; THCA, thyroid carcinoma.

    Journal: Annals of Translational Medicine

    Article Title: A pan-cancer analysis of the oncogenic role of secreted phosphoprotein 1 (SPP1) in human cancers

    doi: 10.21037/atm-22-829

    Figure Lengend Snippet: The RNA expression level of SPP1 in different types of cancer. (A) The SPP1 expression level in tumor and normal tissues in the TIMER2 database (*, P<0.05; **, P<0.01; ***, P<0.001). (B) The expression level of SPP1 in DLBC, LGG, OV, TGCT, and UCS tumor tissues and the corresponding normal tissues of the GTEx database using GEPIA2 (*, P<0.01). (C) Relationship between SPP1 and the pathological stages of BLCA, CESC, ESCA, HNSC, TGCT, LIHC, SKCM, and THCA tumor types. SPP1, secreted phosphoprotein 1; DLBC, diffuse large B cell lymphoma; LGG, brain lower grade glioma; OV, ovarian serous cystadenocarcinoma; TGCT, testicular germ cell tumor; UCS, uterine carcinosarcoma; GTEx, Genotype-Tissue Expression; BLCA, bladder urothelial carcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma; ESCA, esophageal carcinoma; HNSC, head and neck squamous cell cancer; LIHC, liver hepatocellular cancer; SKCM, skin cutaneous melanoma; THCA, thyroid carcinoma.

    Article Snippet: SPP1, secreted phosphoprotein 1; IHC, immunohistochemistry; HPA, the Human Protein Atlas; LGG, brain lower grade glioma; LUAD, lung adenocarcinoma; HNSC, head and neck squamous cell cancer; LIHC, liver hepatocellular cancer; PAAD, pancreatic adenocarcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma.

    Techniques: RNA Expression, Expressing

    Correlation between SPP1 expression and survival prognosis of cancers in TCGA. (A) The heatmap showed the relationship between SPP1 gene expression and OS or DFS in 33 tumor types (quartile or median used as group cutoff value). (B) The survival maps and Kaplan-Meier curves showed OS in ACC, CESC, HNSC, LGG, LIHC, LUAD, UVM, and PAAD tumor types. SPP1, secreted phosphoprotein 1; OS, overall survival; DFS, disease-free survival; ACC, adenoid cystic carcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma; HNSC, head and neck squamous cell cancer; LGG, brain lower grade glioma; LIHC, liver hepatocellular cancer; LUAD, lung adenocarcinoma; UVM, uveal melanoma; PAAD, pancreatic adenocarcinoma.

    Journal: Annals of Translational Medicine

    Article Title: A pan-cancer analysis of the oncogenic role of secreted phosphoprotein 1 (SPP1) in human cancers

    doi: 10.21037/atm-22-829

    Figure Lengend Snippet: Correlation between SPP1 expression and survival prognosis of cancers in TCGA. (A) The heatmap showed the relationship between SPP1 gene expression and OS or DFS in 33 tumor types (quartile or median used as group cutoff value). (B) The survival maps and Kaplan-Meier curves showed OS in ACC, CESC, HNSC, LGG, LIHC, LUAD, UVM, and PAAD tumor types. SPP1, secreted phosphoprotein 1; OS, overall survival; DFS, disease-free survival; ACC, adenoid cystic carcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma; HNSC, head and neck squamous cell cancer; LGG, brain lower grade glioma; LIHC, liver hepatocellular cancer; LUAD, lung adenocarcinoma; UVM, uveal melanoma; PAAD, pancreatic adenocarcinoma.

    Article Snippet: SPP1, secreted phosphoprotein 1; IHC, immunohistochemistry; HPA, the Human Protein Atlas; LGG, brain lower grade glioma; LUAD, lung adenocarcinoma; HNSC, head and neck squamous cell cancer; LIHC, liver hepatocellular cancer; PAAD, pancreatic adenocarcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma.

    Techniques: Expressing

    Correlation between SPP1 DNA methylation and mRNA expression or survival prognosis of cancers in TCGA. (A) Chromosomal distribution of the methylation probes associated with SPP1. (B-H) MEXPRESS plots showed correlation between SPP1 DNA methylation and mRNA expression or survival prognosis of cancers in TCGA. SPP1, secreted phosphoprotein 1; mRNA, messenger RNA; TCGA, The Cancer Genome Atlas.

    Journal: Annals of Translational Medicine

    Article Title: A pan-cancer analysis of the oncogenic role of secreted phosphoprotein 1 (SPP1) in human cancers

    doi: 10.21037/atm-22-829

    Figure Lengend Snippet: Correlation between SPP1 DNA methylation and mRNA expression or survival prognosis of cancers in TCGA. (A) Chromosomal distribution of the methylation probes associated with SPP1. (B-H) MEXPRESS plots showed correlation between SPP1 DNA methylation and mRNA expression or survival prognosis of cancers in TCGA. SPP1, secreted phosphoprotein 1; mRNA, messenger RNA; TCGA, The Cancer Genome Atlas.

    Article Snippet: SPP1, secreted phosphoprotein 1; IHC, immunohistochemistry; HPA, the Human Protein Atlas; LGG, brain lower grade glioma; LUAD, lung adenocarcinoma; HNSC, head and neck squamous cell cancer; LIHC, liver hepatocellular cancer; PAAD, pancreatic adenocarcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma.

    Techniques: DNA Methylation Assay, Expressing, Methylation

    Phosphorylation analysis of SPP1 protein in 4 tumor types. (A-D) Box plots showed the expression level of SPP1 phosphoprotein (NP_001035147.1, S62S63, S195, S219, S234, S254, S263, S258, S280, and T190 sites) between normal tissue and primary tissue of 4 tumor types (BRCA, COAD, LUAD, and UCEC) via the UALCAN based on the CPTAC dataset. SPP1, secreted phosphoprotein 1; BRCA, breast invasive carcinoma; COAD, colon adenocarcinoma; LUAD, lung adenocarcinoma; UCEC, uterine corpus endometrial carcinoma; CPTAC, Clinical Proteomic Tumor Analysis Consortium.

    Journal: Annals of Translational Medicine

    Article Title: A pan-cancer analysis of the oncogenic role of secreted phosphoprotein 1 (SPP1) in human cancers

    doi: 10.21037/atm-22-829

    Figure Lengend Snippet: Phosphorylation analysis of SPP1 protein in 4 tumor types. (A-D) Box plots showed the expression level of SPP1 phosphoprotein (NP_001035147.1, S62S63, S195, S219, S234, S254, S263, S258, S280, and T190 sites) between normal tissue and primary tissue of 4 tumor types (BRCA, COAD, LUAD, and UCEC) via the UALCAN based on the CPTAC dataset. SPP1, secreted phosphoprotein 1; BRCA, breast invasive carcinoma; COAD, colon adenocarcinoma; LUAD, lung adenocarcinoma; UCEC, uterine corpus endometrial carcinoma; CPTAC, Clinical Proteomic Tumor Analysis Consortium.

    Article Snippet: SPP1, secreted phosphoprotein 1; IHC, immunohistochemistry; HPA, the Human Protein Atlas; LGG, brain lower grade glioma; LUAD, lung adenocarcinoma; HNSC, head and neck squamous cell cancer; LIHC, liver hepatocellular cancer; PAAD, pancreatic adenocarcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma.

    Techniques: Expressing

    The protein expression of SPP1 was detected by immunohistochemistry in 6 types of tumor tissues from HPA database (×100 magnifications). (A-F) Tissue microarrays showed the protein expression of SPP1 was detected in LGG, LUAD, HNSC, LIHC, PAAD, CESC tumor tissues and normal tissues. The tissues IHC staining pictures were from The Human Protein Atlas database, which collected and handled samples in accordance with Swedish laws and regulation and obtained samples from the Department of Clinical Pathology, Uppsala University Hospital, Uppsala, Sweden as part of the sample collection governed by the Uppsala Biobank. SPP1, secreted phosphoprotein 1; IHC, immunohistochemistry; HPA, the Human Protein Atlas; LGG, brain lower grade glioma; LUAD, lung adenocarcinoma; HNSC, head and neck squamous cell cancer; LIHC, liver hepatocellular cancer; PAAD, pancreatic adenocarcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma.

    Journal: Annals of Translational Medicine

    Article Title: A pan-cancer analysis of the oncogenic role of secreted phosphoprotein 1 (SPP1) in human cancers

    doi: 10.21037/atm-22-829

    Figure Lengend Snippet: The protein expression of SPP1 was detected by immunohistochemistry in 6 types of tumor tissues from HPA database (×100 magnifications). (A-F) Tissue microarrays showed the protein expression of SPP1 was detected in LGG, LUAD, HNSC, LIHC, PAAD, CESC tumor tissues and normal tissues. The tissues IHC staining pictures were from The Human Protein Atlas database, which collected and handled samples in accordance with Swedish laws and regulation and obtained samples from the Department of Clinical Pathology, Uppsala University Hospital, Uppsala, Sweden as part of the sample collection governed by the Uppsala Biobank. SPP1, secreted phosphoprotein 1; IHC, immunohistochemistry; HPA, the Human Protein Atlas; LGG, brain lower grade glioma; LUAD, lung adenocarcinoma; HNSC, head and neck squamous cell cancer; LIHC, liver hepatocellular cancer; PAAD, pancreatic adenocarcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma.

    Article Snippet: SPP1, secreted phosphoprotein 1; IHC, immunohistochemistry; HPA, the Human Protein Atlas; LGG, brain lower grade glioma; LUAD, lung adenocarcinoma; HNSC, head and neck squamous cell cancer; LIHC, liver hepatocellular cancer; PAAD, pancreatic adenocarcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma.

    Techniques: Expressing, Immunohistochemistry

    SPP1-related gene enrichment analysis. (A) PPI network plot showed experimentally determined SPP1-binding proteins using the STRING tool. (B,C) Based on the SPP1-binding from STRING and the top 100 interacted genes from GEPIA2, KEGG and GO pathway analyses were performed and shown as bubble plots. (D) The cnetplot for the molecular function data in the GO analysis is also shown. (E) The scatter plots showed the first 4 SPP1-corelated genes using the GEPIA2 approach. SPP1, secreted phosphoprotein 1; PPI, protein-protein interaction; STRING, Search Tool for the Retrieval of Interacting Genes; KEGG, Kyoto encyclopedia of genes and genomes; GO, Gene Ontology.

    Journal: Annals of Translational Medicine

    Article Title: A pan-cancer analysis of the oncogenic role of secreted phosphoprotein 1 (SPP1) in human cancers

    doi: 10.21037/atm-22-829

    Figure Lengend Snippet: SPP1-related gene enrichment analysis. (A) PPI network plot showed experimentally determined SPP1-binding proteins using the STRING tool. (B,C) Based on the SPP1-binding from STRING and the top 100 interacted genes from GEPIA2, KEGG and GO pathway analyses were performed and shown as bubble plots. (D) The cnetplot for the molecular function data in the GO analysis is also shown. (E) The scatter plots showed the first 4 SPP1-corelated genes using the GEPIA2 approach. SPP1, secreted phosphoprotein 1; PPI, protein-protein interaction; STRING, Search Tool for the Retrieval of Interacting Genes; KEGG, Kyoto encyclopedia of genes and genomes; GO, Gene Ontology.

    Article Snippet: SPP1, secreted phosphoprotein 1; IHC, immunohistochemistry; HPA, the Human Protein Atlas; LGG, brain lower grade glioma; LUAD, lung adenocarcinoma; HNSC, head and neck squamous cell cancer; LIHC, liver hepatocellular cancer; PAAD, pancreatic adenocarcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma.

    Techniques: Binding Assay

    Correlation analysis between SPP1 expression and immune infiltration. (A) Heatmap showed the relationship between SPP1 and 7 types of immune cells in 32 tumor types. (B) Scatter plots showed significant positive correlation between SPP1 and macrophages, neutrophils, and dendritic cells in BLCA, BRCA, LGG, LIHC, PAAD, and THCA tumor types. (C) Heatmaps showed the relationship between SPP1 and immune stimulators, inhibitors, and chemokines. SPP1, secreted phosphoprotein 1; BLCA, bladder urothelial carcinoma; BRCA, breast invasive carcinoma; LGG, brain lower grade glioma; LIHC, liver hepatocellular cancer; PAAD, pancreatic adenocarcinoma; THCA, thyroid carcinoma.

    Journal: Annals of Translational Medicine

    Article Title: A pan-cancer analysis of the oncogenic role of secreted phosphoprotein 1 (SPP1) in human cancers

    doi: 10.21037/atm-22-829

    Figure Lengend Snippet: Correlation analysis between SPP1 expression and immune infiltration. (A) Heatmap showed the relationship between SPP1 and 7 types of immune cells in 32 tumor types. (B) Scatter plots showed significant positive correlation between SPP1 and macrophages, neutrophils, and dendritic cells in BLCA, BRCA, LGG, LIHC, PAAD, and THCA tumor types. (C) Heatmaps showed the relationship between SPP1 and immune stimulators, inhibitors, and chemokines. SPP1, secreted phosphoprotein 1; BLCA, bladder urothelial carcinoma; BRCA, breast invasive carcinoma; LGG, brain lower grade glioma; LIHC, liver hepatocellular cancer; PAAD, pancreatic adenocarcinoma; THCA, thyroid carcinoma.

    Article Snippet: SPP1, secreted phosphoprotein 1; IHC, immunohistochemistry; HPA, the Human Protein Atlas; LGG, brain lower grade glioma; LUAD, lung adenocarcinoma; HNSC, head and neck squamous cell cancer; LIHC, liver hepatocellular cancer; PAAD, pancreatic adenocarcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma.

    Techniques: Expressing